Author

B. Ludewig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 11

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:mouse· 9 Research Focus:cell type annotation· 6 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

H.-W. Cheng· 3 shared M. Luetge· 3 shared S. Wang· 2 shared A. Casal· 1 shared A. De Martin· 1 shared A. E. Denton· 1 shared A. Esteve-Codina· 1 shared A. Ferreira· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersImmunology

H.-W. Cheng

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11 papers

Recent·Most cited

Sustained innate interferon is an essential inducer of tertiary lymphoid structures

A. L. Calvanese, V. Cecconi, S. Staehli, D. Schnepf, P. Pereira, J. Gschwend, M. Heikenwaelder, C. Schneider, B. Ludewig, K. Silina, M. van den Broek

This study identifies sustained type I interferon signaling as essential for the development of functional tertiary lymphoid structures in the lungs during inflammation.

bioRxiv · Apr 30, 2024Immunology

Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges

A. Geng, R. G. Brenig, J. Roux, M. Luetge, H.-W. Cheng, E. E. Flint, M.-A. Meier, O. T. Pop, P. Kuenzler-Heule, M. McPhail, S. Soysal, D. Semela, M. Heim, C. J. Weston, B. Ludewig, C. Bernsmeier

The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.

bioRxiv · Apr 3, 2024 · PreprintImmunology

B cell-stromal cell cross talk drives mesenteric lymph node eosinophilia during intestinal helminth infection

E. Bessell, R. Finlay, L. K. James, B. Ludewig, N. Harris, M. R. Hepworth, L. K. Dubey

bioRxiv · Oct 28, 2023 · PreprintImmunology

A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease

J. D. Brandstadter, A. De Martin, M. Lutge, A. Ferreira, B. T. Gaudette, Y. Stanossek, S. Wang, M. V. Gonzalez, E. Camiolo, G. Wertheim, B. Austin, D. Allman, M. S. Lim, D. C. Fajgenbaum, J. C. Aster, , I. Maillard

This study demonstrates that cryopreservation of lymphoid tissue allows for the study of non-hematopoietic stromal cells in human disease, preserving cell type proportions and transcriptional profiles.

bioRxiv · Feb 6, 2023Immunology

Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

A. Martinez-Riano, S. Wang, S. Boeing, S. Minoughan, A. Casal, K. M. Spillane, B. Ludewig, P. Tolar

The paper shows that follicular dendritic cells (FDCs) in germinal centers (GCs) have distinct spatial organization that controls antigen retention, with central FDCs acting as long-term antigen reservoirs.

bioRxiv · Sep 6, 2022 · PreprintImmunology

Rapid differentiation of regulatory CD4+ T cells in the infarcted myocardium blunts in situ inflammation

M. Delgobo, E. Weiss, D. E. Ashour, L. Popiolkowski, P. Arampatzi, V. Stangl, P. Arias-Loza, P. Rainer, A.-E. Saliba, B. Ludewig, U. Hofmann, S. Frantz, G. C. Ramos

This study shows that CD4+ T cells in the infarcted heart rapidly become regulatory, reducing inflammation, and identifies mechanisms of their differentiation and function.

bioRxiv · Mar 25, 2022Immunology

TYPE I INTERFERON-DEPENDENT CELLULAR REMODELING DURING ACUTE PULMONARY MHV INFECTION

S. Grabherr, A. Waltenspuehl, M. Luetge, L. Buechler, H.-W. Cheng, K. Zielinska, S. Caviezel-Firner, P. Krebs, B. Ludewig, N. B. Pikor

This study investigates the role of type I interferon in limiting viral spread and inflammation during pulmonary MHV infection, showing its necessity for immune cell maturation and viral containment.

bioRxiv · Feb 1, 2022 · PreprintImmunology

Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages

J. D'Rozario, K. Knoblich, M. Luetge, C. Perez Shibayama, H.-W. Cheng, Y. O. Alexandre, D. Roberts, J. Campos, J. Astarita, E. Dutton, M. Suliman, A. E. Denton, S. J. Turley, R. L. Boyd, S. Mueller, , A. L. Fletcher

This study identifies fibroblastic reticular cells (FRCs) as essential for supporting lymph node-resident macrophages through CSF1 and CSF1R signaling.

bioRxiv · Nov 24, 2021Immunology

Multi-tier mechanics control stromal adaptations in swelling lymph nodes

F. P. Assen, M. Hons, R. Hauschild, S. Shamipour, J. Abe, W. A. Kaufmann, T. Costanzo, G. Krens, M. Brown, B. Ludewig, S. Hippenmeyer, J. V. Stein, C.-P. Heisenberg, E. Hannezo, S. A. Luther, M. Sixt

The paper investigates how lymph nodes accommodate size increases during immune challenges by analyzing biomechanical adaptations of fibroblastic reticular cells and fibroblasts.

bioRxiv · Jul 28, 2021 · PreprintImmunology

Perinatal Programming of Mucosal Stromal Cell Identity by the Lymphotoxin Pathway Regulates Mucosal Immune Responses in the Adult

C. Li, E. Lam, C. Perez-Shibayama, D. Lee, L. A. Ward, A. Nguyen, M. Ahmed, K. V. Korneev, O. Rojas, T. Sun, H. H. He, A. Martin, B. Ludewig, J. L. Gommerman

This study shows that in utero Lymphotoxin-beta receptor signaling programs mesenteric lymph node stromal cells to support adult IgA responses by influencing antibody class switch and IgA+ cell generation.

bioRxiv · Feb 21, 2019Immunology

Time-resolved systems analysis reveals a critical role of XCR1+ 1 dendritic cells in the maintenance of effector T cells during chronic viral infection

J. Argilaguet, M. Pedragosa, A. Esteve-Codina, G. Riera, E. Vidal, C. Peligero-Cruz, D. Andreu, T. Kaisho, G. Bocharov, B. Ludewig, S. Heath, A. Meyerhans

The paper uses time-resolved transcriptomics and immunological analysis to show XCR1+ dendritic cells maintain effector T cells during chronic viral infection.

bioRxiv · Nov 22, 2018Immunology