Author

M. Mutka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. H. Rannikko· 2 shared J. Mattson· 2 shared J. Pouwels· 2 shared L. Niinikoski· 2 shared M. Hollmen· 2 shared P. E. Kovanen· 2 shared R. Liu· 2 shared R. Turpin· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

J. H. Rannikko

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

R. Turpin, K. Peltonen, J. H. Rannikko, R. Liu, A. N. Kumari, D. Nicorici, M. H. Lee, M. Mutka, P. E. Kovanen, L. Niinikoski, T. Meretoja, J. Mattson, P. Järvinen, K. Lahdensuo, R. Järvinen, , J. Klefström

The paper evaluates immunomodulatory drug responses in patient-derived tumor explant models of breast and renal cancer, finding reproducible gene expression and cytokine changes across models.

bioRxiv · May 11, 2024Immunology

Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment

R. Turpin, R. Liu, P. Munne, A. Peura, J. H. Rannikko, G. Philips, B. Boeckx, N. Salmelin, E. Hurskainen, I. Suleymanova, E. M. Vuorinen, L. Lehtinen, M. Mutka, P. E. Kovanen, L. Niinikoski, , J. Klefstrom

The paper uses a patient-derived explant model to show metformin enhances dendritic cell maturation by inhibiting complex I, improving anti-tumor immunity when combined with venetoclax.

bioRxiv · May 10, 2023Cancer Biology