RUNX1-ETO induction rapidly alters chromatin landscape and growth of a specific sub-population of hESC-derived myeloid precursor cells by interfering with RUNX1 regulation
M. Nafria, P. Keane, E. Ng, E. G. Stanley, A. G. Elefanty, C. Bonifer
This study shows that RUNX1-ETO expression in hESC-derived myeloid precursors causes chromatin reprogramming, blocks differentiation, and arrests growth, with effects specific to a sub-population of cells.
bioRxiv · Aug 28, 2019 · PreprintCancer Biology