Author

C. Bonifer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

P. Keane· 4 shared H. Blair· 2 shared L. Ames· 2 shared M. Raghavan· 2 shared O. Heidenreich· 2 shared P. S. Chin· 2 shared S. G. Kellaway· 2 shared S. Potluri· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

P. Keane

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5 papers

Recent·Most cited

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

R. Almaghrabi, Y. Alyayhawi, P. Keane, C. R. J. Ward, R. Bayley, C. Sargas, P. Menendez, G. J. Murphy, T. Sobahy, M. A. Baghdadi, A. F. Flemban, S. Kabrah, I. Akerman, M. Raghavan, E. Barragan, , P. Garcia

This study shows a heterozygous CEBPA mutation in the bZIP domain causes MDS progression by altering chromatin structure and clonal composition, using patient-derived iPSCs.

bioRxiv · Jul 24, 2023Cancer Biology

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

D. J. L. Coleman, P. Keane, R. Luque-Martin, P. S. Chin, H. Blair, L. Ames, S. G. Kellaway, J. Griffin, E. Holmes, S. Potluri, S. A. Assi, J. H. Bushweller, O. T. Heidenreich, P. Cockerill, C. Bonifer

The paper identifies critical transcription factor regulons in FLT3-ITD+ AML by analyzing gene regulatory networks and shows their necessity for AML growth.

bioRxiv · Jul 18, 2023Cancer Biology

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

S. G. Kellaway, S. Potluri, P. Keane, H. Blair, P. S. Chin, A. Ptasinska, A. Worker, L. Ames, A. Adamo, D. J. Coleman, N. Khan, S. Assi, A. Krippner-Heidenreich, M. Raghavan, P. N. Cockerill, , C. Bonifer

This study identifies VEGF and IL-5 signalling pathways as aberrantly activated in t(8;21) leukemic stem cells, enabling their growth and relapse.

bioRxiv · Mar 10, 2023Cancer Biology

RUNX1-ETO induction rapidly alters chromatin landscape and growth of a specific sub-population of hESC-derived myeloid precursor cells by interfering with RUNX1 regulation

M. Nafria, P. Keane, E. Ng, E. G. Stanley, A. G. Elefanty, C. Bonifer

This study shows that RUNX1-ETO expression in hESC-derived myeloid precursors causes chromatin reprogramming, blocks differentiation, and arrests growth, with effects specific to a sub-population of cells.

bioRxiv · Aug 28, 2019 · PreprintCancer Biology

RUNX1/RUNX1T1 controls alternative splicing in the t(8;21)-positive acute myeloid leukemia cells

V. Grinev, I. Ilyushonak, R. Clough, S. Nakjang, J. Smink, N. Martinez-Soria, T. Ramanouskaya, C. Bonifer, O. Heidenreich

This study identifies two mechanisms by which RUNX1/RUNX1T1 regulates alternative splicing in t(8;21)-positive acute myeloid leukemia cells, affecting RNA isoform production and protein structure.

bioRxiv · May 4, 2019 · PreprintCancer Biology