Author

P. Keane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

C. Bonifer· 4 shared H. Blair· 2 shared L. Ames· 2 shared M. Raghavan· 2 shared P. S. Chin· 2 shared S. G. Kellaway· 2 shared S. Potluri· 2 shared A. Adamo· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

C. Bonifer

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Author profile →

5 papers

Recent·Most cited

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

R. Almaghrabi, Y. Alyayhawi, P. Keane, C. R. J. Ward, R. Bayley, C. Sargas, P. Menendez, G. J. Murphy, T. Sobahy, M. A. Baghdadi, A. F. Flemban, S. Kabrah, I. Akerman, M. Raghavan, E. Barragan, , P. Garcia

This study shows a heterozygous CEBPA mutation in the bZIP domain causes MDS progression by altering chromatin structure and clonal composition, using patient-derived iPSCs.

bioRxiv · Jul 24, 2023Cancer Biology

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

D. J. L. Coleman, P. Keane, R. Luque-Martin, P. S. Chin, H. Blair, L. Ames, S. G. Kellaway, J. Griffin, E. Holmes, S. Potluri, S. A. Assi, J. H. Bushweller, O. T. Heidenreich, P. Cockerill, C. Bonifer

The paper identifies critical transcription factor regulons in FLT3-ITD+ AML by analyzing gene regulatory networks and shows their necessity for AML growth.

bioRxiv · Jul 18, 2023Cancer Biology

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

S. G. Kellaway, S. Potluri, P. Keane, H. Blair, P. S. Chin, A. Ptasinska, A. Worker, L. Ames, A. Adamo, D. J. Coleman, N. Khan, S. Assi, A. Krippner-Heidenreich, M. Raghavan, P. N. Cockerill, , C. Bonifer

This study identifies VEGF and IL-5 signalling pathways as aberrantly activated in t(8;21) leukemic stem cells, enabling their growth and relapse.

bioRxiv · Mar 10, 2023Cancer Biology

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV-2 nsp3 Macrodomain

L. M. Sherrill, E. E. Joya, A. Walker, A. Roy, Y. M. Alhammad, M. Atobatele, S. Wazir, G. Abbas, P. Keane, J. Zhuo, A. Leung, D. K. Johnson, L. Lehtio, A. Fehr, D. V. Ferraris

This study designs and synthesizes inhibitors targeting the SARS-CoV-2 nsp3 macrodomain, identifying compound 15c as a low-micromolar inhibitor with structural and thermal evidence of binding.

bioRxiv · Feb 27, 2022 · PreprintBiochemistry

RUNX1-ETO induction rapidly alters chromatin landscape and growth of a specific sub-population of hESC-derived myeloid precursor cells by interfering with RUNX1 regulation

M. Nafria, P. Keane, E. Ng, E. G. Stanley, A. G. Elefanty, C. Bonifer

This study shows that RUNX1-ETO expression in hESC-derived myeloid precursors causes chromatin reprogramming, blocks differentiation, and arrests growth, with effects specific to a sub-population of cells.

bioRxiv · Aug 28, 2019 · PreprintCancer Biology