Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer
C. D. Gatenbee, A.-M. Baker, R. O. Schenck, M. Neves, S. Y. Hasan, P. Martinez, W. C. H. Cross, M. Jansen, M. Rodriguez-Justo, A. Sottoriva, S. Leedham, M. Robertson-Tessi, T. A. Graham, A. Anderson
The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.
bioRxiv · May 3, 2019 · PreprintCancer Biology