A. Anderson

Physiological Processing of Aversiveness in the Mind's Ear: Comparing Audiovisual, Auditory and Imagined Auditory Affective Stimuli

The paper compares physiological responses to aversive and nonaversive audiovisual, auditory, and imagined auditory stimuli, finding consistent EMGc differentiation across modalities.

The collective application of shorebird tracking data to conservation

The paper describes a collaborative effort to integrate shorebird tracking data for conservation, showing how shared data can support conservation actions.

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated Lipogenesis

This study defines the physiological role of wild-type PNPLA3 in maintaining hepatic VLDL-TG secretion and shows that the I148M variant impairs this function during lipogenic conditions.

Learning to Adapt - Deep Reinforcement Learning in Treatment-Resistant Prostate Cancer

This paper applies deep reinforcement learning to adaptive drug scheduling in prostate cancer, showing it can extend time to progression by up to a quarter and outperform current protocols.

Reconstructing colonization dynamics to establish how human activities transformed island biodiversity

The paper develops a process-explicit method to reconstruct human colonization dynamics on islands, showing it can reveal how human activities transformed biodiversity in New Zealand.

H3K36M provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis

This study shows that H3K36M oncohistone disrupts epithelial differentiation, increases cellular plasticity, and drives squamous carcinogenesis by altering histone modifications.

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers

The paper integrates single-cell RNA and protein data from breast cancer samples to identify novel lymphocyte phenotypes and their clinical relevance.

A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

This study evaluates a SARS-CoV-2 Spike ferritin nanoparticle vaccine in cynomolgus macaques, showing strong immunological responses and protection against infection.

A novel camera trap design for studying wildlife in mountain glacier ecosystems yields new insight for glacier biodiversity in the Pacific Northwest, USA

This study tests a novel camera trap design for glacier ecosystems and documents wildlife and human activity in a mountain glacier in the Pacific Northwest.

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

This study evaluates a SARS-CoV-2 spike ferritin nanoparticle vaccine's effectiveness against B.1.1.7 and B.1.351 variants in hamsters, showing protection against disease and viral replication.

Natural variation at the Drosophila melanogaster Or22 odorant receptor locus is associated with changes in olfactory behaviour

The paper shows that variation at the Or22 locus in Drosophila melanogaster affects ab3A neuron responses, leading to changes in olfactory behavior and oviposition site preference.

MLL4 is a critical mediator of differentiation and ferroptosis in the epidermis

This study identifies MLL4's role in promoting epidermal differentiation and ferroptosis, linking it to tumor suppression and skin homeostasis.

A spike-ferritin nanoparticle vaccine induces robust innate immune activity and drives polyfunctional SARS-CoV-2-specific T cells

This study evaluates a spike-ferritin nanoparticle vaccine with adjuvants, showing enhanced T cell responses and cross-reactivity against SARS-CoV and other coronaviruses.

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

This study evaluates an adjuvanted SARS-CoV-2 RBD nanoparticle vaccine in macaques, showing robust immune responses and protection against viral challenge and variants.

Efficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Primates

A SARS-CoV-2 Spike ferritin nanoparticle vaccine induces broad neutralizing antibodies and protects nonhuman primates against respiratory infection and disease.

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

The paper depletes adult microglia using CSF1R inhibition and shows that subventricular zone/white matter myeloid cells dynamically repopulate the brain, exhibiting distinct phenotypes from endogenous microglia.

Spatial structure impacts adaptive therapy by shaping intra-tumoral competition

This study shows how spatial structure affects adaptive therapy by influencing intra-tumoral competition between drug-sensitive and resistant cells.

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.

IsoMaTrix: a framework to visualize the isoclines of matrix games and quantify uncertainty in structured populations

IsoMaTrix visualizes isoclines of matrix games and quantifies uncertainty in structured populations, showing spatial configuration impacts cancer model dynamics under treatment.

Turnover modulates the need for a cost of resistance in adaptive therapy

This study investigates whether a cost of resistance is necessary for adaptive therapy to delay cancer progression, finding that cell turnover modulates this requirement depending on tumor growth conditions.

Mix & Match: Phenotypic coexistence as a key facilitator of solid tumour invasion

This study uses a mathematical model to show that stable coexistence of different cancer cell phenotypes enhances tumour invasion by allowing complementary traits to work synergistically.

Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.

Syndecan-1 facilitates breast cancer metastasis to the brain

This study shows that syndecan-1 promotes breast cancer metastasis to the brain by enhancing cell migration across the blood-brain barrier and altering cytokine secretion.

Antibiotic collateral sensitivity is contingent on the repeatability of evolution

This study shows that sequential antibiotic treatments may overestimate therapeutic benefits due to stochastic resistance or susceptibility outcomes in E. coli.

Acidity promotes tumor progression by altering macrophage phenotype in prostate cancer

This study shows that tumor acidity promotes prostate cancer by altering macrophage phenotype, both in vitro and in vivo, and is supported by in silico modeling.

A natural killer cell gene signature predicts melanoma patient survival

The paper develops an NK cell gene signature to predict survival in metastatic cutaneous melanoma patients using TCGA RNA-seq data.

Dissecting targeted therapy resistance: Integrating models to quantify environment mediated drug resistance

This paper quantifies environmental contributions to drug resistance in melanoma, revealing heterogeneity that impacts treatment dynamics and suggests strategies to target both tumor and stroma.

Homeostasis Back and Forth: An Eco-Evolutionary Perspective of Cancer

The paper discusses how cancer cells disrupt tissue homeostasis and proposes an eco-evolutionary framework to understand tumor progression and treatment.