M. Jansen

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

A single amino acid substitution in MdLAZY1A dominantly impairs shoot gravitropism in Malus

This study identifies a single amino acid substitution in MdLAZY1A that causes weeping growth in apple by impairing gravitropism.

Phenotypic plasticity and genetic control in colorectal cancer evolution

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

The co-evolution of the genome and epigenome in colorectal cancer

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

The scratch-digging lifestyle of the Permian "microsaur" Batropetes as a model for the exaptative origin of jumping locomotion in frogs

This paper proposes that the forelimb adaptations in Batropetes, a Permian microsaur, represent an exaptation from digging behavior that enabled the evolution of jumping in frogs.

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium

The paper studies clonal hepatocyte expansions in normal human livers, finding a periportal progenitor niche and slow clonal expansion dynamics.

Cell-free Expression of Proton-Coupled Folate Transporter in the Presence of Nanodiscs

This study shows that PCFT can be expressed in a cell-free system with nanodiscs, with specific lipids enabling soluble expression.

Evidence that ion conduction in 5-HT3A receptors proceeds through lateral portals in the cytosol

This study investigates ion conduction pathways in 5-HT3A receptors by analyzing disulfide bond formation in engineered cysteines, supporting lateral portals over a vertical pathway.

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

This study finds that severe SARS-CoV-2 infection is associated with stronger antibody and memory B cell responses against the spike protein and nucleocapsid protein.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Hypoxia increases the tempo of evolution in glioblastoma

This study shows hypoxia accelerates tumour evolution by increasing cell division and mutation rates in glioblastoma.

Delineating the site of interaction on the intracellular domain of 5-HT3A receptors with the chaperone protein RIC-3

The paper identifies a 24-amino acid segment in the 5-HT3A intracellular domain that mediates its interaction with the chaperone protein RIC-3.

Low-glutathione mutants are impaired in growth but do not show an increased sensitivity to moderate water deficit

The paper phenotypically characterizes low-glutathione Arabidopsis mutants under control and drought conditions, finding reduced growth but no increased drought sensitivity.

Bupropion inhibits serotonin type 3AB heteromeric channels at a physiologically relevant concentration

This paper shows bupropion inhibits 5-HT3AB receptors at clinically relevant concentrations, with stronger effects on heteromeric than homomeric receptors.

Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.

Triple Arginines as Molecular Determinants for Pentameric Assembly of the Intracellular Domain of 5-HT3A Receptors

This study identifies three arginines in the intracellular domain of 5-HT3A receptors that are critical for pentameric assembly.

Dual role of protease activated receptor 4 in acute kidney injury: contributing to renal injury and inflammation, while maintaining the renal filtration barrier upon acute renal ischemia reperfusion injury

This study investigates the dual role of PAR4 in renal I/R injury, showing it contributes to renal injury and inflammation while maintaining the filtration barrier.

Low genetic variation in tolerance to defoliation in a long-lived tropical understorey palm

The paper quantifies genetic variation in growth and defoliation tolerance in a tropical palm, finding high heritability of growth rate but low genetic variation in tolerance and compensatory responses.

Accuracy, limitations and cost-efficiency of eDNA-based community survey in tropical frogs

This study evaluates the accuracy and cost-efficiency of eDNA-based surveys for tropical frog communities, finding good agreement with field surveys and cost-effectiveness in high-diversity areas.