P. Martinez

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.

The brittle star genome illuminates the genetic basis of animal appendage regeneration

This study presents a chromosome-scale genome assembly of the brittle star and identifies conserved gene expression patterns during regeneration across invertebrates and vertebrates.

Regeneration of Starfish Radial Nerve Cord restores animal mobility and unveils a new coelomocyte population

This study investigates starfish radial nerve cord regeneration, identifying a new coelomocyte population involved in the process.

Spatial transcriptomics reveal pitfalls and opportunities for the detection of rare high-plasticity breast cancer subtypes

The paper uses spatial transcriptomics to identify specific markers for rare high-plasticity breast cancer subtypes, showing that bulk expression signatures are limited by stromal contamination.

Mass Mortality of Marine Mammals Associated to Highly Pathogenic Influenza Virus (H5N1) in South America

The paper reports a mass mortality event of over 3,000 sea lions in Peru linked to H5N1 influenza virus, suggesting possible transmission from infected wild birds.

Cell cortex microtubules contribute to division plane positioning during telophase in maize

The paper shows that cortical microtubules interact with division-site proteins to guide phragmoplast positioning during telophase in maize.

A combined characterization of coelomic fluid cell types in the spiny starfish Marthasterias glacialis: inputs from flow cytometry and imaging

The paper characterizes coelomic fluid cell types in the spiny starfish Marthasterias glacialis using flow cytometry and imaging, identifying two main populations with distinct morphological and functional features.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Modeling adaptive therapy in non-muscle invasive bladder cancer

This study models adaptive therapy for non-muscle invasive bladder cancer to control tumor size and reduce recurrence by analyzing mutational heterogeneity and cytokine profiles.

TANGLED1 mediates interactions between microtubules that may promote spindle organization and phragmoplast guidance to the division site in maize

This study shows TAN1 binds microtubules, influencing spindle organization and phragmoplast guidance in maize by mediating microtubule interactions.

Beyond parallel evolution: when several species colonize the same environmental gradient

The paper examines genomic divergence in four flatfish species colonizing the North Sea-Baltic Sea gradient, finding heterogeneous divergence patterns and no parallel genomic architecture.

Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.

Quantifying local malignant adaptation in tissue-specific evolutionary trajectories by harnessing cancer’s repeatability at the genetic level

The paper quantifies local malignant adaptation in cancer by analyzing genetic convergence and divergence across 2,742 cancer genomes, revealing environmental adaptation differences between pre-malignant lesions and metastatic clones.

Predicting division planes of three-dimensional cells by soap-film minimization

The paper develops a mathematical model to predict cell division planes in plants and animals by simulating soap-film minima, showing it matches observed division sites and avoids unfavorable junctions.