A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models
J. M. Hoolachan, E. McCallion, E. R. Sutton, O. Cetin, P. Pacheco-Torres, M. Dimitriadi, M. Okoh, L. M. Walter, P. Claus, M. J. Wood, D. P. Tonge, M. Bowerman
The paper identifies 580 drug candidates with similar activities to prednisolone in SMA models using transcriptomics and drug repositioning, but only some show potential as SMA treatments.
bioRxiv · Jun 14, 2023Pathology