PDZ Domains from the Junctional Proteins Afadin and ZO-1 Act as Mechanosensors
V. T. Vachharajani, M. P. DeJong, S. Dutta, J. Chapman, E. Ghosh, A. Singharoy, A. R. Dunn
This study shows that PDZ domains from afadin and ZO-1 act as mechanosensors, forming catch bonds or weakening under mechanical force, affecting cell-cell adhesion stability.
bioRxiv · Sep 24, 2023 · PreprintBiophysics