Cancer BiologybioRxivPreprint
A paracrine circuit of IL-1b/IL-1R1 between myeloid and tumor cells drives glioblastoma progression
Z. Chen, B. Giotti, M. Kaluzova…·D. Hambardzumyan
The paper identifies a paracrine IL-1β/IL-1R1 circuit between myeloid and tumor cells that drives glioblastoma progression and shows that antagonizing this circuit reduces tumor growth and extends survival.
DOI 10.1101/2022.04.03.486888