Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
S. Hegde, B. Giotti, B. Y. Soong, L. Halasz, J. Le Berichel, A. Magen, B. Kloeckner, R. Mattiuz, M. D. Park, A. Marks, M. Belabed, P. Hamon, T. Chin, L. Troncoso, J. J. Lee, , M. Merad
The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.
bioRxiv · Jun 24, 2024Immunology
B. Giotti, K. Dolasia, w. Zhao, P. Cai, R. Sweeney, E. Merritt, E. Kiner, G. Kim, A. Bhagwat, S. Hegde, B. Fitzgerald, S. Shroff, T. Dawson, M. Garcia-Barros, J. Abdul-Ghafar, , A. Tsankov
This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.
bioRxiv · Mar 14, 2024Cancer Biology
S. Mzoughi, M. Schwarz, X. Wang, D. Demircioglu, G. Ulukaya, K. Mohammed, F. Di Tullio, C. Company, Y. Dramaretska, M. Leushacke, B. Giotti, T. Lannagan, D. Lozano-Ojalvo, D. Hasson, A. Tsankov, , E. Guccione
This study identifies an oncofetal cell state that contributes to resistance in colorectal cancer and shows that targeting both this state and LGR5+ CSCs is needed for effective treatment.
bioRxiv · Dec 10, 2023Cancer Biology
A. Waghray, I. Monga, B. Lin, V. Shah, M. Slyper, B. Giotti, J. Xu, J. Waldman, D. Dionne, L. T. Nguyen, W. Lou, P. Cai, E. Park, C. Muus, J. Sun, , J. Rajagopal
This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.
bioRxiv · Nov 28, 2023 · PreprintCell Biology
W. Zhao, B. Kepecs, N. R. Mahadevan, A. Segerstolpe, J. L. Weirather, N. R. Besson, B. Giotti, B. Y. Soong, C. Li, S. Vigneau, M. Slyper, I. Wakiro, J. Jane-Valbuena, O. Ashenberg, A. Rotem, , A. M. Tsankov
This study constructs a multi-omic atlas of TP53-mutant lung adenocarcinoma tumors, revealing altered cellular identity, gene expression programs, and spatial interactions in the tumor microenvironment.
bioRxiv · Jun 28, 2023 · PreprintCancer Biology
Z. Chen, N. Soni, G. Pinero, B. Giotti, D. J. Eddins, K. E. Lindblad, J. L. Ross, N. Tsankova, D. H. Gutmann, S. Lira, A. Lujambio, E. E. B. Ghosn, A. M. Tsankov, D. Hambardzumyan
This paper shows that eliminating monocyte chemoattraction increases neutrophil infiltration in glioblastoma, promoting tumor aggression, and that targeting both monocytes and neutrophils improves survival in mouse models.
bioRxiv · Jul 21, 2022 · PreprintImmunology
A. Magen, P. Hamon, N. Fiaschi, L. Troncoso, E. Humblin, D. D'souza, T. Dawson, M. D. Park, J. Kim, S. Hamel, M. Buckup, C. Chang, A. Tabachnikova, H. Schwartz, N. Malissen, , Merad
The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.
bioRxiv · Jun 22, 2022 · PreprintImmunology
Z. Chen, B. Giotti, M. Kaluzova, C. Herting, G. Pinero, m. p. vallcorba, S. Cristea, J. L. Ross, J. Ackley, V. Maximov, F. Szulzewsky, M. Marquez-Ropero, A. Angione, N. Nichols, N. Tsankkova, , D. Hambardzumyan
The paper identifies a paracrine IL-1β/IL-1R1 circuit between myeloid and tumor cells that drives glioblastoma progression and shows that antagonizing this circuit reduces tumor growth and extends survival.
bioRxiv · Apr 3, 2022 · PreprintCancer Biology