Fidaxomicin jams M. tuberculosis RNA polymerase motions needed for initiation via RbpA contacts
H. Boyaci, J. Chen, M. Lilic, M. Palka, R. A. Mooney, R. Landick, S. A. Darst, E. A. Campbell
This study determines the structure of M. tuberculosis RNA polymerase with fidaxomicin, revealing how it inhibits transcription by blocking essential motions.
bioRxiv · Jan 8, 2018Biophysics