Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development
L. M. Paardekooper, Y. E. Fillie-Grijpma, A. J. van der Sluijs-Gelling, M. Zlei, R. van Doorn, M. H. Vermeer, M. Paunovic, M. J. Titulaer, S. M. van der Maarel, J. J. M. van Dongen, J. J. Verschuuren, M. G. Huijbers
The paper investigates why IgG4 autoantibodies predominate in certain autoimmune diseases and finds that B cell development is normal, suggesting antigen-driven subclass predominance rather than B cell dysfunction.
bioRxiv · Jun 30, 2023Immunology