Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development
L. M. Paardekooper, Y. E. Fillie-Grijpma, A. J. van der Sluijs-Gelling…·M. G. Huijbers
The paper investigates why IgG4 autoantibodies predominate in certain autoimmune diseases and finds that B cell development is normal, suggesting antigen-driven subclass predominance rather than B cell dysfunction.