β-L-1- uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity
C. De, D. Liu, D. Depledge, J. Breuer, U. S. Singh, C. Hartline, M. Prichard, C. K. Chu, J. F. Moffat
This study shows L-BHDU's effectiveness against VZV and HSV-1 relies on thymidine kinase activity, as resistant strains have mutations in TK that impair drug phosphorylation.
bioRxiv · Feb 13, 2020 · PreprintMicrobiology