Disruption of integrin alpha-5/beta-1-dependent transforming growth factor beta-1signaling pathway attenuates vessel co-option in colorectal cancer liver metastases
M. Rada, A. Kapelanski-Lamoureux, O. Zlotnik, S. Petrillo, A. Lazaris, P. Metrakos
This study shows that inhibiting the integrin alpha-5/beta-1 pathway reduces vessel co-option in colorectal cancer liver metastases by suppressing TGFβ1-driven Ang1 expression.
bioRxiv · May 24, 2022 · PreprintCancer Biology