Author

J. Bloom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:mouse· 1

Frequent Co-Authors

A. C. Walls· 2 shared A. Greaney· 2 shared J. E. Bowen· 2 shared M. A. Tortorici· 2 shared T. N. Starr· 2 shared A. Addetia· 1 shared A. Blackstone· 1 shared A. De Marco· 1 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

A. C. Walls

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

F. Roesch, C. Cereghino, L. Carrau, A. Hardy, H. Ribeiro-Filho, A. Henrion Lacritick, C. Koh, J. Marano, T. A. Bates, P. Rai, C. Chuong, S. Akter, T. Vallet, H. Blanc, T. Elliot, , J. Weger-Lucarelli

This paper identifies a mutation in the E2 glycoprotein of Mayaro virus that enhances transmission in Aedes aegypti but reduces replication in human cells, suggesting a trade-off in host adaptation.

bioRxiv · Apr 5, 2022 · PreprintMicrobiology

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody

M. A. Tortorici, N. Czudnochowski, T. N. Starr, R. Marzi, A. C. Walls, F. Zatta, J. E. Bowen, S. Jaconi, J. di Iulio, Z. Wang, A. De Marco, S. Zepeda, D. Pinto, Z. Liu, M. Beltramello, , J. Bloom

This paper identifies a human monoclonal antibody that broadly neutralizes SARS-CoV-2 variants and zoonotic sarbecoviruses by targeting a conserved epitope on the spike protein.

bioRxiv · Apr 7, 2021 · PreprintImmunology

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

A. C. Walls, M. C. Miranda, M. N. Pham, A. Schaefer, A. Greaney, P. S. Arunachalam, M.-J. Navarro, M. A. Tortorici, K. Rogers, M. A. O'Connor, L. Shireff, D. E. Ferrell, N. Brunette, E. Kepl, J. E. Bowen, , Veesler

This study shows that a SARS-CoV-2 RBD nanoparticle vaccine protects against SARS-CoV-2 and related sarbecoviruses, including variants, in mice and non-human primates.

bioRxiv · Mar 15, 2021Immunology

Cancer cells induce hepatocytes apoptosis in co-opted colorectal cancer liver metastatic lesions

M. Rada, M. Tsamchoe, A. Kapelanski-Lamoureux, J. Bloom, S. Petrillo, D. H. Kim, A. Lazaris, P. Metrakos

The paper investigates apoptosis in hepatocytes during colorectal cancer liver metastasis and finds that cancer cells induce hepatocyte apoptosis to replace them in co-opted lesions.

bioRxiv · Feb 11, 2021 · PreprintCancer Biology

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

J. Dong, S. Zost, A. Greaney, T. N. Starr, A. S. Dingens, E. C. Chen, R. Chen, B. Case, R. Sutton, P. Gilchuk, J. Rodriguez, E. Armstrong, C. Gainza, R. Nargi, E. Binshtein, , J. E. Crowe

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

bioRxiv · Jan 27, 2021 · PreprintImmunology