Cancer BiologybioRxivPreprint
Disruption of integrin alpha-5/beta-1-dependent transforming growth factor beta-1signaling pathway attenuates vessel co-option in colorectal cancer liver metastases
M. Rada, A. Kapelanski-Lamoureux, O. Zlotnik…·P. Metrakos
This study shows that inhibiting the integrin alpha-5/beta-1 pathway reduces vessel co-option in colorectal cancer liver metastases by suppressing TGFβ1-driven Ang1 expression.
DOI 10.1101/2022.05.24.493291