Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection
M. Aravantinou, O. Mizenina, T. Brill, J. Kenney, C. Timmons, I. Frank, A. Gettie, B. Grasperge, J. Blanchard, A. Salazar, J. D. Lifson, M. Robbiani, N. Derby
This study investigates how HSV-2 and polyICLC immune stimulation affects SIV vaccine efficacy in rhesus macaques, finding that mucosal immune activation can enhance control of viremia in breakthrough infections.
bioRxiv · Jun 2, 2020 · PreprintImmunology