B. Grasperge

High IL-1β and IL-18 Levels Associate with Gut Barrier Disruption and Monocyte Activation During Chronic SIV Infection with Long-Term Suppressive Antiretroviral Therapy

This study links elevated IL-1β and IL-18 levels with gut barrier disruption and monocyte activation in SIV-infected macaques on long-term ART, suggesting a role in CVD and metabolic complications.

Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection

This study investigates how HSV-2 and polyICLC immune stimulation affects SIV vaccine efficacy in rhesus macaques, finding that mucosal immune activation can enhance control of viremia in breakthrough infections.

A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

This study evaluates a subcutaneous TAF implant for HIV prevention, finding it achieves sustained drug levels but causes severe local inflammation and necrosis in rabbits and macaques.

Protection of rhesus macaques against vaginal SHIV challenges by VRC01 and an anti-α4β7 antibody

This study shows that combining VRC01 and Rh-4β7 antibodies delays SHIV infection, preserves CD4+ T cells, and alters immune responses in macaques.