Establishment of a human three-dimensional chip-based chondro-synovial co-culture joint model for reciprocal cross-talk studies in arthritis research
M. Rothbauer, R. A. Byrne, S. Schobesberger, I. Olmos Calvo, A. Fischer, E. Reihs, S. Spitz, B. E. M. Bachmann, F. Sevelda, J. Holinka, W. Holnthoner, H. Redl, S. Toegel, R. Windhager, H. P. Kiener, P. Ertl
This study establishes a 3D microfluidic co-culture model of synovial and chondral organoids to study reciprocal cross-talk in arthritis, showing enhanced cartilage physiology and cytokine responses in co-cultures.
bioRxiv · Feb 19, 2021Bioengineering