A. Fischer

Functional rescue of critical-size bone defect using molecular network analysis of axolotl limb regeneration.

The paper identifies molecular differences between regenerating blastema and non-regenerating CSD in axolotl limbs and uses Wnt3a expression to induce cartilage bridging in CSD.

Linear β-1,2-glucans trigger immune hallmarks and disease resistance in plants

This paper identifies specific β-1,2-glucans that trigger immune responses and disease resistance in plants by enhancing ROS production and defense gene expression in Arabidopsis and other crops.

Productivity of the eelgrass biotope and the resilience of fisher-hunter-gatherers in prehistoric Denmark

This study uses isotopic analysis of marine vertebrate remains to show the critical role of eelgrass biotopes in the diet and subsistence strategies of prehistoric fisher-hunter-gatherers in Denmark.

The aging-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

Age-dependent RGS5 loss in pericytes induces cardiac dysfunction and fibrosis in the heart

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.

Guidelines for performing ribosome profiling in plants including structural analysis of rRNA fragments

This paper provides guidelines for performing ribosome profiling in plants, including methods to remove rRNA contaminants and structural insights into rRNA fragments.

Bioengineering of a human innervated cardiac muscle model

This paper introduces a human innervated cardiac muscle model that demonstrates functional neuro-cardiac junctions and serves as a surrogate system for studying brain-heart diseases.

Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation

The paper investigates the differential roles of CTPS1 and CTPS2 in cell proliferation, finding that CTPS1 is more critical for cell growth than CTPS2.

Enhanced inflammatory signaling driven by metabolic switch in Aicardi-Goutieres syndrome

This study identifies a metabolic switch and loss of HIF-1 activity in AGS patients, showing that stabilizing HIF-1 reduces inflammation and IP-10 production.

The Selection Landscape and Genetic Legacy of Ancient Eurasians

This study models ancient Eurasian selection landscapes and shows ancestry-specific genetic risk associations with modern phenotypes.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.

HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer

This study identifies HAPLN1 as a driver of peritoneal metastasis in pancreatic cancer by enhancing tumor cell plasticity and immunomodulation.

Population Genomics of Postglacial Western Eurasia

This study analyzes ancient genomes from Western Eurasia to trace postglacial human migrations and genetic changes across the Holocene.

Remorin proteins serve as membrane topology scaffolds in plants

The paper shows remorin proteins stabilize membrane tubules and curvature during symbiotic infections in plants.

Endothelial Rbpj is essential for the education of tumour-associated macrophages

This study shows that endothelial Rbpj promotes TAM education in EOC by regulating CXCL2, which drives CD44 expression and cholesterol depletion in TAMs, creating an immunosuppressive TME.

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

This study shows that deleting TSC22D4 in hepatocytes reduces liver damage in NASH by improving mitochondrial function and lipid metabolism.

Methylglyoxal Induces Endothelial Dysfunction via Stunning

This study shows that methylglyoxal induces reversible endothelial dysfunction through a non-proliferative state and cellular stunning, mediated by MG-H1 turnover.

Actin dynamics regulation by TTC7A/PI4KIIIα axis limits DNA damage and cell death during leukocyte migration

This study shows TTC7A deficiency impairs leukocyte migration, leading to DNA damage and cell death during chemotaxis in dense environments.

Semaphorin 3C exacerbates liver fibrosis

This study identifies SEMA3C as a key driver of liver fibrosis by enhancing TGF-β signaling in hepatic stellate cells.

Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity

This study develops a human hypaxial muscle model from pluripotent stem cells with functional maturation and regenerative capacity for studying muscle biology and disease.

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

Establishment of a human three-dimensional chip-based chondro-synovial co-culture joint model for reciprocal cross-talk studies in arthritis research

This study establishes a 3D microfluidic co-culture model of synovial and chondral organoids to study reciprocal cross-talk in arthritis, showing enhanced cartilage physiology and cytokine responses in co-cultures.

Feed efficiency of lactating Holstein cows was not as repeatable across diets as within diet over subsequent lactation stages

This study found feed efficiency in lactating Holstein cows was more repeatable within diets than reproducible across diets, but cow rankings were not significantly affected by diet changes.

The Oncogenic Function of PLAGL2 is Mediated via Specific Target Genes Through a Wnt-independent Mechanism in Colorectal Cancer

This study identifies PLAGL2 as a key driver of colorectal cancer by promoting proliferation and cell cycle progression through direct target genes IGF2 and ASCL2, independent of Wnt signaling.

Validating the use of bovine buccal sampling as a proxy for the rumen microbiota using a time course and random forest classification approach

This paper validates buccal swab sampling as a non-invasive proxy for rumen microbiota by optimizing sampling timing and using random forest classification to identify discriminatory taxa.

Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages

This study shows that different oils cause varying levels of peritoneal inflammation and macrophage depletion, with peanut oil causing severe chronic inflammation and olive oil promoting inflammation resolution.

Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche

This study investigates how post-myocardial infarction heart failure affects the bone vascular niche, showing age-independent loss of type H endothelium and increased inflammatory gene expression in human bone marrow endothelium.

Photorespiration pathways in a chemolithoautotroph

This study identifies a novel photorespiration pathway in chemolithoautotrophic bacteria, revealing the glycerate pathway as the main route and the malate cycle as an oxidative alternative.

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis

This study shows that lipid droplets in brown adipose tissue are not required for cold-induced thermogenesis, as mice lacking triglyceride synthesis enzymes maintain thermogenic function through alternative fuel sources.

RpiRc regulates RsbU to modulate eDNA-dependent biofilm formation and in vivo virulence of Staphylococcus aureus in a mouse model of catheter infection

This study identifies RpiRc as a regulator of eDNA-dependent biofilm formation and virulence in S. aureus, showing reduced biofilm formation and antibiotic tolerance in its mutant.