Cobalt-sulfur coordination chemistry drives B12 loading onto methionine synthase
R. Mascarenhas, A. Guha, Z. Li, M. Ruetz, S. An, J. Seravalli, R. Banerjee
This study identifies how MMADHC uses Co-S coordination lability to transfer cobalamin to methionine synthase, explaining homocystinuria caused by MMADHC variants.
bioRxiv · Jul 25, 2023 · PreprintBiochemistry