S. An

Phase Contrast Tomography (PCT)

This paper introduces phase contrast tomography (PCT) for 3D phase imaging, demonstrating its high resolution and stability for imaging microspheres and sub-organelles.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

Cobalt-sulfur coordination chemistry drives B12 loading onto methionine synthase

This study identifies how MMADHC uses Co-S coordination lability to transfer cobalamin to methionine synthase, explaining homocystinuria caused by MMADHC variants.

Discovery of the apiosyltransferase, celery UGT94AX1 that catalyzes the biosynthesis of a flavone glycoside, apiin

This paper identifies celery UGT94AX1 as the apiosyltransferase responsible for apiin biosynthesis and characterizes its substrate specificity and key residues.

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

This study designs synthetic oligomeric ligands to modulate FGFR signaling and shows their impact on vascular cell fate decisions.

Quantitative model of aging-related muscle degeneration: a Drosophila study

This study quantifies aging-related muscle degeneration in Drosophila, showing genetic and neuronal factors contribute to muscle fiber loss.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

Mechanistic insights of glucosome condensate formation by stochastic modeling approaches

This study uses stochastic modeling to investigate how PFKL's biological properties drive glucosome condensate formation in human cells.

High-content quantitative high-throughput screening identifies a cell cycle-associated signaling cascade that regulates a multienzyme metabolic assembly for glucose metabolism

This study identifies a cell cycle-associated signaling cascade regulating PFK1-mediated glucosome assembly through high-content screening and validation.

Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

This paper introduces magneto-gas vesicles (MGVs) for non-invasive in vivo imaging of tissue mechanics, showing improved sensitivity and resolution compared to existing methods.

Functional regulation of 4D metabolic network between multienzyme glucosome condensates and mitochondria

The paper investigates how glucosomes and mitochondria form a 4D metabolic network to regulate glucose metabolism in human cells.

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

This study shows that exocyst-mediated exocytosis regulates PI(3,4,5)P3 levels and AKT activation in response to EGF signaling in epithelial cells.

Functional oscillation of a multienzyme glucosome assembly during cell cycle progression

The paper discovers that glucosomes oscillate during the cell cycle in human cells, linking their size-dependent spatiotemporal dynamics to glucose metabolism's role in cell cycle progression.

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

An auto-inhibitory mechanism regulates the non-enzymatic functions of a histone demethylase

The paper shows Epe1 regulates epigenetic inheritance through non-enzymatic interactions with Swi6HP1 and Clr3, independent of its catalytic activity.

YAP/TAZ as a Novel Regulator of cell volume

This study identifies YAP/TAZ as regulators of single-cell volume, showing their role extends beyond cell cycle duration and shape, and they influence division volume independently of mTOR.

Microbial Cells Harboring a Mitochondrial Gene Are Capable of CO2 Capture

This study identifies a mitochondrial gene, OG1, capable of CO2 capture in engineered microorganisms, suggesting its potential for mitigating global warming through biological CO2 capture in barren lands.

MMOD-induced structural changes of hydroxylase in soluble methane monooxygenase

The paper reports the crystal structure of the MMOH-MMOD complex, revealing how MMOD inhibits MMOH catalytic activity by competing with MMOB and altering the di-iron centre geometry.

Integrative structure investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

This study investigates the structure of the Importin4_histone H3/H4_Asf1a complex and identifies key interactions between Importin4 and the histone H3 tail.