A. Guha

Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

NEUROEPITHELIAL BODIES AND TERMINAL BRONCHIOLES ARE NICHES FOR DISTINCTIVE CLUB CELLS THAT CAN REPAIR AIRWAYS FOLLOWING ACUTE NOTCH INHIBITION

This study investigates how Notch inhibition affects airway club cells, showing that a subpopulation can repair airways by reverting to a progenitor state.

H2S preconditioning induces long-lived perturbations in O2 metabolism

This study shows that H2S preconditioning causes long-lasting changes in O2 metabolism, including increased P50(O2) and metabolic memory effects lasting up to 24-48 hours.

Cobalt-sulfur coordination chemistry drives B12 loading onto methionine synthase

This study identifies how MMADHC uses Co-S coordination lability to transfer cobalamin to methionine synthase, explaining homocystinuria caused by MMADHC variants.

Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis

This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.

A redox cycle with complex II promotes sulfide quinone oxidoreductase dependent H2S oxidation

The paper identifies a redox cycle involving complex II and SQOR that sustains H2S oxidation when complex IV is inhibited, improving H2S clearance in cells exposed to microbiota-derived H2S.

The Fragile X Mental Retardation Protein protects the lung from xenobiotic stress by facilitating the Integrated Stress Response

This study shows FMRP protects lung cells from stress by enabling the Integrated Stress Response, with similar effects observed in mice and human cells.

Niclosamide inhibits SARS-CoV2 entry by blocking internalization through pH-dependent CLIC/GEEC endocytic pathway

Response of whole plant water use to limiting light and water conditions are independent of each other in seedlings of seasonally dry tropical forests

The paper examines how water use and light availability independently affect seedlings in seasonally dry tropical forests, finding that water use responses are largely independent of light conditions.