Tau seeds translocate across the cell membrane to initiate aggregation
D. A. Dodd, M. S. LaCroix, C. Valdez, G. M. Knox, A. R. Vega, A. Kumar, C. Xing, C. L. White, M. I. Diamond
This study identifies a novel mechanism by which tau seeds enter cells and initiate aggregation through direct translocation across the plasma membrane, independent of endocytosis.
bioRxiv · May 10, 2022 · PreprintCell Biology