Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity
J. Paukstyte, R. M. Lopez Cabezas, Y. Feng, K. Tong, D. Schnyder, E. Elomaa, P. Gregorova, M. Doudin, M. Sarkka, J. Sarameri, A. Lippi, H. Vihinen, J. Juutila, A. Nieminen, P. Toronen, , J. Saarikangas
The paper identifies age-related protein structural changes in yeast and shows that inhibiting polymerization of glutamate synthase extends lifespan.
bioRxiv · Jan 23, 2023Cell Biology