Y. Feng

Structures of PSI-FCPI from Thalassiosira pseudonana in high light provide convergent evolution and light-adaptive strategies in diatom FCPIs

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans

The study reconstructs the Yunxian 2 cranium and shows it belongs to the Homo longi clade, likely including Denisovans, and is closely related to the H. sapiens clade.

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

Automated Cytometric Gating with Human-Level Performance Using Bivariate Segmentation

This paper introduces UNITO, a deep learning framework for automated cytometric gating that matches human performance and provides interpretable results without requiring manual input.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis

This study shows that host 5-HT levels influence Plasmodium transmission in mosquitoes by modulating mitochondrial homeostasis and reactive oxygen species.

Discovery and characterization of chromosomal inversions in the arboviral vector mosquito Aedes aegypti

This study identifies chromosomal inversions in Aedes aegypti using Hi-C, revealing geographic distribution patterns and potential roles in host choice and disease transmission.

Variant Surface Protein GP60 Contributes to Host Infectivity of Cryptosporidium parvum

The paper investigates the role of GP60 in Cryptosporidium parvum infectivity, finding that while GP60 is not essential, its cleavage products affect parasite growth and infection severity.

Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility

This study investigates how glycan-induced structural activation of the HPV capsid facilitates entry by reducing intercapsomere flexibility.

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing

The study identifies SKSR1 as a key virulence factor in Cryptosporidium by crossing isolates with different virulence and analyzing genetic loci associated with infectivity.

Generative AI for Cardiac Organoid Florescence Generation

This paper uses conditional GANs to colorize brightfield images of cardiac organoids, providing cell type-specific fluorescence information to enhance their characterization.

Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity

This study shows that microinfarcts in mice enhance recurrent stroke severity via NLRP3-dependent trained immunity in microglia.

A removable and cosmopolitan dsRNA Toti-like virus causes latent infection in a model diatom strain

The paper identifies a dsRNA Totiviridae virus in two diatom strains, shows it can be removed to create virus-free lines, and suggests it causes latent infection rather than lytic infection.

RNA-guided RNA silencing by an Asgard archaeal Argonaute

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

Cultivation of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids for cryopreservation of isolates and transcriptomic studies of infection

This paper develops a method to cultivate and cryopreserve Cryptosporidium hominis and C. parvum using enteroids, showing improved transcriptomic responses compared to conventional cell systems.

Parsing digital or analogue TCR performance through piconewton forces

The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response

This study shows that oncogenic Ras in zebrafish skin triggers phenotypic plasticity in specific keratinocytes and promotes tumour-promoting neutrophils within 24 hours.

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

This study uses single-cell transcriptomics to show that targeting CD74-positive macrophages enhances neoadjuvant therapy efficacy in cervical cancer by altering tumor microenvironment interactions.

One-pot virus detection based on isothermal amplificationcoupled with temperature-activated argonaute

This paper develops a one-step virus detection method using immobilized thermotolerant Ago to separate amplification and cleavage steps, achieving high sensitivity and specificity.

Using the pan-genomic framework for the discovery of genomic islands in the haloarchaeon Halorubrum ezzemoulense

This study uses pan-genomics to identify 50 genomic islands in Halorubrum ezzemoulense, revealing rare accessory genes and homeocassettes that contribute to adaptability and speciation.

Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold

This study investigates the evolution of viperin genes across prokaryotes and eukaryotes, revealing their conservation, diversification mechanisms, and immune functions.

Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3

This study identifies METTL3-mediated stabilization of RRBP1 mRNA via m6A in prostate cancer and develops small-peptide inhibitors to target this pathway.

A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

LncRNA SNHG16 modulates paclitaxel resistance in breast cancer by regulating Let-7a-5p/DUSP7

This study shows that SNHG16 promotes paclitaxel resistance in breast cancer by suppressing Let-7a-5p and upregulating DUSP7, suggesting the SNHG16-Let-7a-5p-DUSP7 axis as a potential therapeutic target.

De novo Protein Sequence Design Based on Deep Learning and Validation on CalB Hydrolase

The paper designs novel protein sequences using a Graphormer-based model and validates them on CalB hydrolase, achieving 1.7x higher specific activity than the wild type.

Metabolic Nutrient Preferences of Vibrio mimicus: Leveraging Nucleotides and Oligopeptides from Yellow Catfish for Enhanced Infectivity

This study identifies host-specific metabolites that enhance Vibrio mimicus infectivity in yellow catfish by providing nutrients like deoxyguanosine.