Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
E. Trofimenko, G. Grasso, M. Heulot, N. Chavalier, M. A. Deriu, G. Dubuis, Y. Arribat, M. Serulla, S. Michel, G. Vantomme, F. Ory, L. C. Dam, J. P. Puyal, F. Amati, A. Luthi, , C. Widmann
This study identifies potassium channels that modulate CPP translocation by lowering transmembrane potential, revealing a mechanism involving megapolarization and water pore formation.
bioRxiv · Feb 25, 2020Cell Biology