H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
D. Dibitetto, M. Liptay, F. Vivalda, E. Gogola, H. Dogan, M. G. Fernandez, A. Duarte, J. A. Schmid, S. T. Durant, J. V. Forment, I. Klebic, M. Siffert, R. de Brujin, A. N. Kousholt, N. A. Marti, , S. Rottenberg
This study identifies H2AX's role in promoting replication fork degradation and chemosensitivity in BRCA-deficient tumours, independent of its classical DNA damage signalling function.
bioRxiv · May 22, 2023Cancer Biology