S. Rottenberg

TurboID mapping reveals exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata

This study uses TurboID proximity labeling to identify secreted effector proteins from Theileria annulata, revealing nine nuclear and four cytosolic candidates, eight of which are intrinsically disordered proteins absent in non-transforming species.

Host metabolic pathways essential for malaria and related hemoparasites in the infection of nucleated cells

The paper identifies host metabolic pathways essential for malaria and related hemoparasites by combining a metabolic model and CRISPR screen.

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

This study identifies H2AX's role in promoting replication fork degradation and chemosensitivity in BRCA-deficient tumours, independent of its classical DNA damage signalling function.

Charting the Heterogeneity of Colorectal Cancer Consensus Molecular Subtypes using Spatial Transcriptomics

This study uses spatial transcriptomics and single-cell RNA sequencing to analyze colorectal cancer subtypes, revealing intratumoral heterogeneity and cell communication events in CMS2 carcinomas.

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer

This study establishes a canine mammary tumor organoid biobank to model human breast cancer, showing genetic and phenotypic conservation and utility for drug testing and CRISPR screening.

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

This study shows that PSMC3IP and MND1 depletion increases PARP inhibitor sensitivity in mitotic cells through impaired D-loop formation and homology-directed repair.

Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double-deficient Cells by Exposing ssDNA Gaps

This study identifies loss of LIG3 as a factor that reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by increasing ssDNA gaps.

Radiosensitivity is an acquired vulnerability of PARPi-resistant BRCA1-deficient tumors

This study identifies radiotherapy as a therapeutic target for BRCA1-deficient tumors that have developed resistance to PARP inhibitors through 53BP1 pathway inactivation.