M. Stevanovic

Dynamical model of antibiotic responses linking expression of resistance to metabolism explains emergence of heterogeneity during drug exposures

The paper constructs a dynamical model linking antibiotic resistance expression and metabolism to explain population heterogeneity during drug exposure in E. coli.

Nutrient gradients mediate creation of highly resistant layers in structured microbial populations during antibiotic exposures

The paper shows how nutrient gradients in structured microbial populations enhance antibiotic resistance through dynamic environmental feedback and gene expression changes.

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

The paper shows that metabolic regulation differences explain the frequent occurrence of lasR loss-of-function mutations in Pseudomonas aeruginosa, linking them to disease severity and evolution.