D. Schultz

Quantifying forms and functions of intestinal bile acid pools in mice

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.

Dynamics of drug delivery determines course of evolution of antibiotic responses in bacteria

This study shows that the dynamics of antibiotic exposure influence the type of mutations that evolve in bacteria, with gradual exposure leading to adaptive mutations and periodic exposure causing loss of regulatory control.

Dispersal of a dominant competitor can drive multispecies coexistence in biofilms

This study shows that biased dispersal of a dominant bacterial species prevents competitive exclusion, enabling coexistence in multispecies biofilms.

Dynamical model of antibiotic responses linking expression of resistance to metabolism explains emergence of heterogeneity during drug exposures

The paper constructs a dynamical model linking antibiotic resistance expression and metabolism to explain population heterogeneity during drug exposure in E. coli.

Community composition and the environment modulate the population dynamics of type VI secretion in human gut bacteria

The paper shows that T6SS in B. fragilis is lost in adults but can be favored or disfavored in mice depending on community composition and ecological conditions.

HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

This study shows that hypomorphic HD-PTP/PTPN23 mice develop lipodystrophy and reduced adipogenesis, indicating HD-PTP's role in insulin signaling and fat accumulation.

Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system

This study develops a polymicrobial biofilm model of the CF lung to investigate community-specific antimicrobial resistance and identifies LasR loss-of-function as a driver of tobramycin tolerance through increased phenazine production.

Marine particle microbiomes during a spring diatom bloom contain active sulfate-reducing bacteria

The paper analyzes marine particle microbiomes during a spring diatom bloom and identifies active sulfate-reducing bacteria in the particulate fraction.

Influenza A Virus Exacerbates Group A Streptococcus Infection and Thwarts Anti-bacterial Inflammatory Responses in Murine Macrophages

This study shows that influenza A virus worsens Group A Streptococcus infection in mice by reducing anti-bacterial inflammatory responses in macrophages.

Nutrient gradients mediate creation of highly resistant layers in structured microbial populations during antibiotic exposures

The paper shows how nutrient gradients in structured microbial populations enhance antibiotic resistance through dynamic environmental feedback and gene expression changes.

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

The paper shows that metabolic regulation differences explain the frequent occurrence of lasR loss-of-function mutations in Pseudomonas aeruginosa, linking them to disease severity and evolution.

Force-induced changes of PilY1 drive surface sensing by Pseudomonas aeruginosa

This study shows that force-induced conformational changes in PilY1, a TFP tip protein, are required for surface sensing in Pseudomonas aeruginosa, affecting c-di-GMP signaling and biofilm formation.

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents

The paper validates in vitro human lung tissue models for studying SARS-CoV-2 and influenza virus infections and antiviral treatments.

An expedited approach towards the rationale design of non-covalent SARS-CoV-2 main protease inhibitors with in vitro antiviral activity

This study designs non-covalent SARS-CoV-2 Mpro inhibitors using structure-based design and Ugi-4CR reactions, identifying 23R as the most potent compound with antiviral activity.

Drug repurposing screens reveal FDA approved drugs active against SARS-Cov-2

The paper screens FDA-approved drugs against SARS-CoV-2 in different cell types, identifying three FDA-approved antivirals with potential for clinical use.

A robust metaproteomics pipeline for a holistic taxonomic and functional characterization of microbial communities from marine particles

This paper develops a robust metaproteomics pipeline for analyzing marine particle-associated bacteria, identifying over 5,000 protein groups and revealing functional differences between free-living and particle-associated communities.

Clonal evaluation of early onset prostate cancer by expression profiling of ERG, SPINK1, ETV1, and ETV4 on whole mount radical prostatectomy tissue