D. Hogan

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis

This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.

Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system

This study develops a polymicrobial biofilm model of the CF lung to investigate community-specific antimicrobial resistance and identifies LasR loss-of-function as a driver of tobramycin tolerance through increased phenazine production.

An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa

This study identifies an rRNA fragment from human airway epithelial cell extracellular vesicles that enhances P. aeruginosa sensitivity to ciprofloxacin by downregulating the MexHI-OpmD efflux pump.

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

The paper shows that metabolic regulation differences explain the frequent occurrence of lasR loss-of-function mutations in Pseudomonas aeruginosa, linking them to disease severity and evolution.

qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps

qFit 3 automates multiconformer modeling of dynamic proteins from X-ray and cryo-EM data, offering improved efficiency and accessibility.

A Multimodal Strategy Used By A Large c-di-GMP Network

The paper investigates a large c-di-GMP network in Pseudomonas fluorescens, showing it uses multimodal regulation to control biofilm formation across nutrient conditions.