Pharmacology & ToxicologybioRxiv
A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar
J. A. Watson, T. Lamb, J. Holmes…·E. A. Ashley
This paper proposes a Bayesian adaptive design for antivenom dose-finding trials, showing it can identify optimal doses with fewer patients than traditional methods.
DOI 10.1371/journal.pntd.0008109