Iron and lipocalin-2 modulate cellular responses in the tumor micro-environment of pancreatic ductal adenocarcinoma
V. Pita-Grisanti, A. W. Dangel, K. Gumpper, A. Ludwig, O. Ueltschi, X. M. Mo, M. Pietrzak, A. Webb, R. F. Hwang, M. Traczek, N. Badi, Z. Cruz-Monserrate
This study shows that iron and lipocalin-2 (LCN2) influence PDAC cell behavior and metastasis, with LCN2 deletion reducing metastasis and iron chelation increasing anti-metastatic gene expression.
bioRxiv · Jan 14, 2020 · PreprintCancer Biology