A. Ludwig

Modelling Inflammatory Endothelial Dysfunction: A Human In Vitro Platform for Translational Research

This study develops an in vitro model to assess endothelial dysfunction under inflammatory stress and finds that combined LPS and PBMC exposure significantly impairs endothelial confluence and increases adhesion molecule expression.

HCN channels sense temperature and determine heart rate responses to heat

The paper identifies a conserved motif in HCN4 channels that mediates heat sensing and modulates heart rate responses to thermal energy.

PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells.

This study shows that PALS1 regulates tight junction protein localization at bicellular junctions in renal epithelial cells, preventing increased paracellular permeability.

Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

This study identifies a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells using proximity proteomics and mass spectrometry.

Cellular Uptake of His-Rich Peptide Coacervates Occurs by a Macropinocytosis-Like Mechanism

This study investigates how His-rich peptide coacervates enter cells, finding they use a macropinocytosis-like mechanism involving cytoskeleton rearrangement and filopodia capture.

Effects of land use and weather on the presence and abundance of mosquito-borne disease vectors in a urban and agricultural landscape in Eastern Ontario, Canada

This study examines how weather and land use affect mosquito species occurrence and abundance in Eastern Ontario, finding that temperature, precipitation, and land cover types significantly influence these factors.

Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at the base of primary cilia and suppresses ciliary elongation

This study identifies Angiomotin isoform 2 as a KIF13B interactor that recruits PALS1 to the base of primary cilia, regulating ciliary length by modulating KIF13B cargo binding.

Enterococcus faecalis persists and replicates within epithelial cells in vitro and in vivo during wound infection

This study shows Enterococcus faecalis persists and replicates within epithelial cells in vitro and in vivo during wound infection, using macropinocytosis to avoid lysosomal degradation.

Comparable environmental stability and disinfection profiles of the currently circulating SARS-CoV-2 variants of concern B.1.1.7 and B.1.351

This study compares the environmental stability and disinfection profiles of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the wildtype, finding comparable susceptibility to disinfection and surface stability.

Iron and lipocalin-2 modulate cellular responses in the tumor micro-environment of pancreatic ductal adenocarcinoma

This study shows that iron and lipocalin-2 (LCN2) influence PDAC cell behavior and metastasis, with LCN2 deletion reducing metastasis and iron chelation increasing anti-metastatic gene expression.

Feasibility analysis of semiconductor voltage nanosensors for neuronal membrane potential sensing

This study develops semiconductor voltage-sensitive nanorods for neuronal membrane potential sensing and demonstrates their feasibility for single-particle detection.

Quantitative proximity proteomics resolves the epithelial apical-lateral border and uncovers a vertebrate marginal zone defined by the polarity protein Pals1

The paper uses proximity proteomics to map the apical-lateral border in MDCK-II cells, identifying a new membrane compartment defined by Pals1.

Population and conservation genomics of the world's rarest hyena species, the brown hyena (Parahyena brunnea)

This study analyzes the population and conservation genomics of the brown hyena, revealing low genetic diversity and potential sub-populations, with implications for its conservation.