Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
C. Zitzmann, C. Dächert, B. Schmid, H. van der Schaar, M. van Hemert, A. S. Perelson, F. van Kuppeveld, R. Bartenschlager, M. Binder, L. Kaderali
This paper develops a mathematical model of plus-strand RNA virus replication for HCV, DENV, and CVB3, identifying viral RNA translation and polyprotein cleavage as key targets for broad-spectrum antiviral strategies.
bioRxiv · Jul 25, 2022Microbiology