MicrobiologybioRxiv
Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
C. Zitzmann, C. Dächert, B. Schmid…·L. Kaderali
This paper develops a mathematical model of plus-strand RNA virus replication for HCV, DENV, and CVB3, identifying viral RNA translation and polyprotein cleavage as key targets for broad-spectrum antiviral strategies.
DOI 10.1371/journal.pcbi.1010423