Author

C. Zitzmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:rat· 1

Frequent Co-Authors

A. S. Perelson· 4 shared R. M. Ribeiro· 3 shared L. Kaderali· 2 shared R. Bartenschlager· 2 shared R. Ke· 2 shared A. Mueller· 1 shared B. Bruegger· 1 shared B. Cerikan· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

A. S. Perelson

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Author profile →

5 papers

Recent·Most cited

Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4+ T cells

N. Sambaturu, E. J. Fray, F. Wu, C. Zitzmann, F. R. Simonetti, D. H. Barouch, J. D. Siliciano, R. F. Siliciano, R. M. Ribeiro, A. S. Perelson, C. Molina-Paris, T. Leitner

The paper models SIV provirus divergence in CD4+ T cells, finding that short-lived cells harbor more diverged virus, while long-lived cells contain less diverged virus, explaining contradictory prior results on reservoir timing.

bioRxiv · Nov 3, 2023 · PreprintMicrobiology

Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody

T. Phan, C. Zitzmann, K. W. Chew, D. M. Smith, E. S. Daar, D. A. Wohl, J. J. Eron, J. S. Currier, M. D. Hughes, M. C. Choudhary, R. Deo, J. Z. Li, R. M. Ribeiro, R. Ke, A. S. Perelson

This paper models viral resistance emergence in SARS-CoV-2 treated with anti-spike monoclonal antibodies, showing that target cell replenishment mechanisms can explain high viral rebounds.

bioRxiv · Sep 14, 2023Immunology

How reliable are estimates of key parameters in viral dynamic models?

C. Zitzmann, R. Ke, R. M. Ribeiro, A. S. Perelson

This study evaluates how reliable parameter estimates are in viral dynamic models when pre-peak viral load data are missing, finding that some parameters are less sensitive to data gaps than others.

bioRxiv · Aug 17, 2023 · PreprintImmunology

Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies

C. Zitzmann, C. Dächert, B. Schmid, H. van der Schaar, M. van Hemert, A. S. Perelson, F. van Kuppeveld, R. Bartenschlager, M. Binder, L. Kaderali

This paper develops a mathematical model of plus-strand RNA virus replication for HCV, DENV, and CVB3, identifying viral RNA translation and polyprotein cleavage as key targets for broad-spectrum antiviral strategies.

bioRxiv · Jul 25, 2022Microbiology

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

K. Tabata, V. Prasad, D. Paul, J.-Y. Lee, M.-T. Pham, W.-I. Twu, C. J. Neufeldt, M. Cortese, B. Cerikan, C. S. Tran, C. Luechtenborg, P. Vkovski, K. Hoermann, A. Mueller, C. Zitzmann, , R. Bartenschlager

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

bioRxiv · May 10, 2021Microbiology