Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity
K. Ahmadzadeh, M. Pereira, M. Vanoppen, E. Bernaerts, J.-H. Ko, T. Mitera, C. Maksoudian, B. B. Manshian, S. Soenen, C. D. Rose, P. Matthys, C. Wouters, J. Behmoaras
This study shows that multinucleation in human macrophages reduces mononuclear phagocyte identity and enables specialized functions in multinucleated giant cells.
bioRxiv · Aug 22, 2022Cell Biology