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M.-H. Hsiao

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Evolutionary Biology· 1

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Organism:E. coli· 1 Approach:experimental assay· 1

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A. F. Rubin· 1 shared B. Wang· 1 shared C. E. Gonzalez· 1 shared D. Rohm· 1 shared E.-Y. Tsou· 1 shared F. W. Stearns· 1 shared J. D. Mehlhoff· 1 shared M. Ostermeier· 1 shared

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1 shared paperEvolutionary Biology

A. F. Rubin

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Evolutionary BiologybioRxivMar 4, 2020

Collateral fitness effects of mutations

J. D. Mehlhoff, F. W. Stearns, D. Rohm…·M. Ostermeier

This study identifies collateral fitness effects of mutations in E. coli, showing that 42% of missense mutations in TEM-1 β-lactamase are deleterious through mechanisms unrelated to protein function.

DOI 10.1073/pnas.1918680117

E. coliexperimental assay

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