Clinical cure of chronic hepatitis B is dependent on activation and perpetuation of robust CD4+ T cell responses
Jillian M. Jespersen, Lia Avanesyan, Jean Publicover, Nicholas D. Carey, Ravi K. Patel, Austin W. Edwards, Sarah Stenske, Jae Hyun Shin, Jiajing Li, Margaret Simone, Nayvin W. Chew, Nicholas Wong, Suprita Trilok, Ann L. Erickson, Arjun Arkal Rao, , Jody L. Baron
The paper identifies shared mechanisms of HBsAg seroclearance using a mouse model and longitudinal PBMCs from CHB patients, showing CD4+ T cell activation is essential for clinical cure.
bioRxiv · Sep 29, 2025 · PreprintImmunology