Author

Nicholas Wong

University of California San DiegoPrimary ORCID profile (0000-0002-2831-2415 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Nicholas WongiD2 papers · University Health Network

Biology Disciplines

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Biophysics· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:E. coli· 1

Frequent Co-Authors

Adil E. WakiliD· 1 shared Alexis J. CombesiD· 1 shared Ali PunjaniiD· 1 shared Ann L. EricksoniD· 1 shared Arjun Arkal RaoiD· 1 shared Austin W. EdwardsiD· 1 shared Bernhard Ørn PalssoniD· 1 shared Christina Wang· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperImmunology

Adil E. WakilORCID

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3 papers

Recent·Most cited

End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC

CryoSPARC Team, Kelly Barber, Hannah R. Bridges, Suhail Dawood, Katherine Elder, Nick Frasser, Fiona Hu, Serena Liu, M. McLean, Ryan Narine, Telisha Ng, Valentin Peretroukhin, Ali Punjani, Harris Snyder, Kye Stachowski, , Nicholas Wong

This paper automates repeat-target cryo-EM structure determination in CryoSPARC, achieving high-resolution results for 21 GPCR datasets with minimal human intervention.

bioRxiv · Oct 17, 2025 · PreprintBiophysics

Clinical cure of chronic hepatitis B is dependent on activation and perpetuation of robust CD4+ T cell responses

Jillian M. Jespersen, Lia Avanesyan, Jean Publicover, Nicholas D. Carey, Ravi K. Patel, Austin W. Edwards, Sarah Stenske, Jae Hyun Shin, Jiajing Li, Margaret Simone, Nayvin W. Chew, Nicholas Wong, Suprita Trilok, Ann L. Erickson, Arjun Arkal Rao, , Jody L. Baron

The paper identifies shared mechanisms of HBsAg seroclearance using a mouse model and longitudinal PBMCs from CHB patients, showing CD4+ T cell activation is essential for clinical cure.

bioRxiv · Sep 29, 2025 · PreprintImmunology

A systems approach discovers the role and characteristics of seven LysR type transcription factors in Escherichia coli

Irina A. Rodionova, Ye Gao, Jonathan M. Monk, Ying Hefner, Nicholas Wong, Richard Szubin, Hyun Gyu Lim, Dmitry A. Rodionov, Zhongge Zhang, Milton H. Saier, Bernhard Ørn Palsson

The paper identifies the functions of seven LysR-type transcription factors in E. coli using multi-omics methods, revealing their roles in nitrogen source utilization and amino acid metabolism.

Scientific Reports · May 4, 2022Peer-reviewedSystems Biology