Loss of restriction-modification methyltransferases drives persistence to fluoroquinolones in Pseudomonas aeruginosa
Maureen Micaletto, Nicolas Oswaldo Gomez, Anna Olina, Aleksei Agapov, Urszula Łapińska, Matthias Preuße, Maria Garcia Castillo, Christian Hacker, Rafael Cantón, Stineke van Houte, Susanne Häussler, Edze Rients Westra, Stefano Pagliara
This study shows that loss of type I restriction-modification methyltransferases in Pseudomonas aeruginosa increases fluoroquinolone persistence through enhanced SOS response and slower growth.
bioRxiv · Sep 26, 2026 · PreprintMicrobiology