BioengineeringMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewed
Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell types
John P. McGinnis, Joshua Ortiz‐Guzman, Maria Camila Guevara…·Benjamin Russell Arenkiel
This study shows common AAV vectors transduce multiple human brain cell types in organotypic slices, with astrocytes showing the most protein expression, and introduces a pipeline for optimizing AAV vectors.
6 citations