Cancer BiologybioRxiv
Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype in AML cells through TGF-β-p38-ALDH2 pathway
Bin Yuan, Fouad El Dana, Stanley Ly…·Venkata Lokesh Battula
This study identifies the TGF-β-p38-ALDH2 pathway as a mechanism by which bone marrow stromal cells induce an ALDH+ stem cell-like phenotype in AML cells, promoting chemotherapy resistance.
DOI 10.1371/journal.pone.0242809