GenomicsGenome MedicinePeer-reviewed
circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics
Izabela Plumbom, Benedikt Obermayer, Raphael Raspe…·Thomas Conrad
The paper introduces circVDJ-seq for efficient T cell receptor profiling from single-cell and spatial multi-omics data, revealing distinct immune microenvironments and T cell clonality patterns in various clinical contexts.